BindingDB logo
myBDB logout

BDBM50415486 CHEMBL592663

SMILES: CN(c1ccccc1)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1

InChI Key: InChIKey=KVIRNGUKXLWHPN-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50415486   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50415486
PNG
(CHEMBL592663)
Show SMILES CN(c1ccccc1)S(=O)(=O)CCNc1nc(nc2ccc(Cl)cc12)N1CCN(C)CC1
Show InChI InChI=1S/C22H27ClN6O2S/c1-27-11-13-29(14-12-27)22-25-20-9-8-17(23)16-19(20)21(26-22)24-10-15-32(30,31)28(2)18-6-4-3-5-7-18/h3-9,16H,10-15H2,1-2H3,(H,24,25,26)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.37n/an/an/an/an/an/an/an/a



Griffin Discoveries BV

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells


J Med Chem 53: 2390-400 (2010)


Article DOI: 10.1021/jm901379s
BindingDB Entry DOI: 10.7270/Q2G44RJ4
More data for this
Ligand-Target Pair