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BDBM50415770 CHEMBL1079516

SMILES: CNC1CN(C1)c1nc(N)nc2c1CCCC21CCCC1

InChI Key: InChIKey=FNLKLDDVROBECF-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50415770   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 Receptor


(Rattus norvegicus (rat))
BDBM50415770
PNG
(CHEMBL1079516)
Show SMILES CNC1CN(C1)c1nc(N)nc2c1CCCC21CCCC1
Show InChI InChI=1S/C16H25N5/c1-18-11-9-21(10-11)14-12-5-4-8-16(6-2-3-7-16)13(12)19-15(17)20-14/h11,18H,2-10H2,1H3,(H2,17,19,20)
KEGG

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.45n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-histamine from rat histamine H4 receptor after 1 hr by liquid scintillation counting


Bioorg Med Chem Lett 20: 1900-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.131
BindingDB Entry DOI: 10.7270/Q21V5G6X
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415770
PNG
(CHEMBL1079516)
Show SMILES CNC1CN(C1)c1nc(N)nc2c1CCCC21CCCC1
Show InChI InChI=1S/C16H25N5/c1-18-11-9-21(10-11)14-12-5-4-8-16(6-2-3-7-16)13(12)19-15(17)20-14/h11,18H,2-10H2,1H3,(H2,17,19,20)
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KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.51n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-histamine from human histamine H4 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem Lett 20: 1900-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.131
BindingDB Entry DOI: 10.7270/Q21V5G6X
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50415770
PNG
(CHEMBL1079516)
Show SMILES CNC1CN(C1)c1nc(N)nc2c1CCCC21CCCC1
Show InChI InChI=1S/C16H25N5/c1-18-11-9-21(10-11)14-12-5-4-8-16(6-2-3-7-16)13(12)19-15(17)20-14/h11,18H,2-10H2,1H3,(H2,17,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.76n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from rat histamine H3 receptor expressed in C6 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem Lett 20: 1900-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.131
BindingDB Entry DOI: 10.7270/Q21V5G6X
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50415770
PNG
(CHEMBL1079516)
Show SMILES CNC1CN(C1)c1nc(N)nc2c1CCCC21CCCC1
Show InChI InChI=1S/C16H25N5/c1-18-11-9-21(10-11)14-12-5-4-8-16(6-2-3-7-16)13(12)19-15(17)20-14/h11,18H,2-10H2,1H3,(H2,17,19,20)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
63.1n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in C6 cells after 1 hr by liquid scintillation counting


Bioorg Med Chem Lett 20: 1900-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.131
BindingDB Entry DOI: 10.7270/Q21V5G6X
More data for this
Ligand-Target Pair