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BDBM50416612 CHEMBL1222601

SMILES: Fc1ccc(CNC(=O)[C@@H]2CCC(=O)N2c2ccccc2)c(Cl)c1

InChI Key: InChIKey=JNSRNGGEURVOEO-XISACWJONA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50416612   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM50416612
PNG
(CHEMBL1222601)
Show SMILES Fc1ccc(CNC(=O)[C@@H]2CCC(=O)N2c2ccccc2)c(Cl)c1
Show InChI InChI=1/C18H16ClFN2O2/c19-15-10-13(20)7-6-12(15)11-21-18(24)16-8-9-17(23)22(16)14-4-2-1-3-5-14/h1-7,10,16H,8-9,11H2,(H,21,24)/t16-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human P2X7 receptor by ethidium bromide release assay


Bioorg Med Chem Lett 20: 5080-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.07.033
BindingDB Entry DOI: 10.7270/Q289173T
More data for this
Ligand-Target Pair