BDBM50416875 AMG-073::AMG073 HCL::CINACALCET::CINACALCET HYDROCHLORIDE::US9487494, Cinacalcet

SMILES: C[C@H](c1cccc2c1cccc2)NCCCc3cccc(c3)C(F)(F)F

InChI Key: InChIKey=VDHAWDNDOKGFTD-UHFFFAOYSA-N

Data: 3 IC50  4 EC50

PDB links: 6 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50416875   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 2D6 (Human)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	7.4	37
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Cytochrome P450 2D6 (Human)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
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Extracellular calcium-sensing receptor (Human)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
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Angiotensin-converting enzyme 2 (Human)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Replicase polyprotein 1ab (2019-nCoV)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Extracellular calcium-sensing receptor (Human)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	19.9	n/a	n/a	n/a	n/a
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Extracellular calcium-sensing receptor (Human)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
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Glycine receptor subunit alpha-1 (Human)	BDBM50416875 (CINACALCET | AMG-073 | AMG073 HCL | CINACALCET HYD...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
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