BDBM14031 5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one::CHEMBL1233300::HA-1100::Hydroxyfasudil

SMILES: O=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1

InChI Key: InChIKey=ZAVGJDAFCZAWSZ-UHFFFAOYSA-N

Data: 4 KI  3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 14031   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Human)	BDBM14031 (CHEMBL1233300 | 5-(1,4-diazepane-1-sulfonyl)-1,2-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	759	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 2 (Human)	BDBM14031 (CHEMBL1233300 | 5-(1,4-diazepane-1-sulfonyl)-1,2-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	575	n/a	n/a	n/a	n/a	n/a	n/a
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C-C motif chemokine 2 (Human)	BDBM14031 (CHEMBL1233300 | 5-(1,4-diazepane-1-sulfonyl)-1,2-d...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 1 (Human)	BDBM14031 (CHEMBL1233300 | 5-(1,4-diazepane-1-sulfonyl)-1,2-d...) Show SMILES Show InChI	GoogleScholar	UniChem		31.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Rho-associated protein kinase 1 (Human)	BDBM14031 (CHEMBL1233300 | 5-(1,4-diazepane-1-sulfonyl)-1,2-d...) Show SMILES Show InChI	GoogleScholar	UniChem		150	-9.46	n/a	n/a	n/a	n/a	n/a	7.6	30
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cAMP-dependent protein kinase catalytic subunit alpha (Mouse)	BDBM14031 (CHEMBL1233300 | 5-(1,4-diazepane-1-sulfonyl)-1,2-d...) Show SMILES Show InChI	GoogleScholar	UniChem		2.20E+3	-7.84	n/a	n/a	n/a	n/a	n/a	7.6	30
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM14031 (CHEMBL1233300 | 5-(1,4-diazepane-1-sulfonyl)-1,2-d...) Show SMILES Show InChI	GoogleScholar	UniChem		7.94E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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