BDBM50418244 CHEMBL1765733::D3RKN_92

SMILES Nc1n[nH]c2cc(ccc12)-c1cc(nc(N)n1)N1CCC[C@H](C1)C(=O)Nc1ccccc1

InChI Key InChIKey=CQRFXINTEFATOH-OAHLLOKOSA-N

Data  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50418244   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418244(CHEMBL1765733 | D3RKN_92)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418244(CHEMBL1765733 | D3RKN_92)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418244(CHEMBL1765733 | D3RKN_92)
Affinity DataIC50:  7.94E+3nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50418244(CHEMBL1765733 | D3RKN_92)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2023More data for this Ligand-Target Pair
In DepthDetails PubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418244(CHEMBL1765733 | D3RKN_92)
Affinity DataIC50:  126nMAssay Description:Inhibition of PDK1-mediated AKT phosphorylation at Thr308 residue in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50418244(CHEMBL1765733 | D3RKN_92)
Affinity DataKd:  1.00E+4nMAssay Description:D3R2021More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418244(CHEMBL1765733 | D3RKN_92)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed