BindingDB logo
myBDB logout

BDBM50420277 CHEMBL2089320

SMILES: COC(=O)C(N1C(c2ccc(OC)cc2)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(Cl)cc1

InChI Key: InChIKey=JYOIWJYTIQLODF-UHFFFAOYNA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50420277   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50420277
PNG
(CHEMBL2089320)
Show SMILES COC(=O)C(N1C(c2ccc(OC)cc2)C(=S)Nc2cc(Cl)ccc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1/C25H20Cl2N2O4S/c1-32-18-10-5-14(6-11-18)21-23(34)28-20-13-17(27)9-12-19(20)24(30)29(21)22(25(31)33-2)15-3-7-16(26)8-4-15/h3-13,21-22H,1-2H3,(H,28,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.19E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of MDM2 binding domain assessed as inhibition of p53 binding to MDM2 after 1 hr by fluorescence polarization assay


Eur J Med Chem 56: 10-16 (2012)


Article DOI: 10.1016/j.ejmech.2012.08.003
BindingDB Entry DOI: 10.7270/Q2K938SR
More data for this
Ligand-Target Pair