BDBM50423736 CHEMBL591543

SMILES COc1ccnc(NCC2CCN(CC2)c2ccc(CC(NC(=O)c3c(C)cc(C)cc3C)C(O)=O)cc2)c1

InChI Key InChIKey=OPEFUTCWWOFWSN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50423736   

TargetIntegrin alpha-5(Homo sapiens (Human))
Shire Orphan Therapies

US Patent
LigandPNGBDBM50423736(CHEMBL591543)
Affinity DataIC50: <100nMpH: 9.6 T: 2°CAssay Description:Fibronectin was diluted with coating buffer (15 mM Na2CO3, 35 mM NaHCO3, pH 9.6) and coated with 100 uL/well to Nunc-Immuno maxisorp plates (Nalge Nu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-IIb(Homo sapiens (Human))
Shire Orphan Therapies

US Patent
LigandPNGBDBM50423736(CHEMBL591543)
Affinity DataIC50: >1.00E+3nMpH: 9.6 T: 2°CAssay Description:Fibrinogen was diluted with coating buffer (15 mM Na2CO3, 35 mM NaHCO3, pH 9.6) and coated with 100 uL/well to Nunc-Immuno maxisorp plates over night...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50423736(CHEMBL591543)
Affinity DataIC50:  0.920nMAssay Description:Inhibition of integrin alpha5beta1 receptor by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-5/beta-1(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50423736(CHEMBL591543)
Affinity DataIC50:  34nMAssay Description:Inhibition of integrin alpha5beta1 receptor-mediated HEK293 cell adhesionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50423736(CHEMBL591543)
Affinity DataIC50:  3.54E+3nMAssay Description:Inhibition of integrin alpha5beta5 receptor by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50423736(CHEMBL591543)
Affinity DataIC50:  3.44E+4nMAssay Description:Inhibition of integrin alpha2bbeta3 receptor by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50423736(CHEMBL591543)
Affinity DataIC50:  89nMAssay Description:Inhibition of integrin alpha5beta3 receptor by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed