BDBM50425862 CHEMBL2312654
SMILES CN(C)C1CCC(CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cc(C)no1
InChI Key InChIKey=ZTSOUDMNSOYCTG-UHFFFAOYSA-N
Data 32 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 50425862
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of PAK4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of NEK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of MYLK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 470nMAssay Description:Inhibition of MST2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 3.84E+3nMAssay Description:Inhibition of MASK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of MARK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPK1/ERK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of MAP4K4 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of MAP3K9 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of LCK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of JAK3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 6.18E+3nMAssay Description:Inhibition of INSR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKKi (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKK-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 7.74E+3nMAssay Description:Inhibition of GSK3-beta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of ECK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of CLK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of CK1-delta (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 7.97E+3nMAssay Description:Inhibition of CHK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 3.88E+3nMAssay Description:Inhibition of CAMK1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibition of BTK (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of Aurora-A (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of AKT1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of ABL (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of P-selectin aggregation in platelet surface (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK6/cyclin D3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair