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BDBM50426542 CHEMBL2323942

SMILES: CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccccc1

InChI Key: InChIKey=NNPJKGJLZBWICB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50426542   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 4 (TRPV4)


(Homo sapiens (Human))
BDBM50426542
PNG
(CHEMBL2323942)
Show SMILES CC(C)Nc1nc2c(C(=O)N(C)C)c(Cl)c(Cl)cc2n1C1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H29Cl2N5O/c1-15(2)27-24-28-22-19(14-18(25)21(26)20(22)23(32)29(3)4)31(24)17-10-12-30(13-11-17)16-8-6-5-7-9-16/h5-9,14-15,17H,10-13H2,1-4H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV4 expressed in BacMam virus infected HEK MSRII cells assessed as inhibition of GSK1016790A-induced calci...


ACS Med Chem Lett 4: 293-6 (2013)


Article DOI: 10.1021/ml300449k
BindingDB Entry DOI: 10.7270/Q2VT1TDB
More data for this
Ligand-Target Pair