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BDBM50426600 CHEMBL2325896

SMILES: O=C(N[C@H](C1CC1)C(=O)N1CC(C1)C#N)c1c[nH]c2ncc(nc12)C1CC1

InChI Key: InChIKey=MIHIZGXUSZQEJD-GGYSOQFKNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50426600   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50426600
PNG
(CHEMBL2325896)
Show SMILES O=C(N[C@H](C1CC1)C(=O)N1CC(C1)C#N)c1c[nH]c2ncc(nc12)C1CC1
Show InChI InChI=1/C19H20N6O2/c20-5-10-8-25(9-10)19(27)15(12-3-4-12)24-18(26)13-6-21-17-16(13)23-14(7-22-17)11-1-2-11/h6-7,10-12,15H,1-4,8-9H2,(H,21,22)(H,24,26)/t15-/s2
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Similars

Article
PubMed
n/an/a 206n/an/an/an/an/an/a



Hoffmann-La Roche

Curated by ChEMBL


Assay Description
Inhibition of JAK2 in human PBMC expressing CD14 assessed as inhibition of GM-CSF-stimulated STAT5a phosphorylation after 30 mins by flow cytometric ...


J Med Chem 56: 345-56 (2013)


Article DOI: 10.1021/jm301646k
BindingDB Entry DOI: 10.7270/Q2Q241JX
More data for this
Ligand-Target Pair