BDBM50426797 CHEMBL2322764

SMILES CC(C)n1ncnc1-c1cc2CCOc3cc(ccc3-c2s1)C(N)=O

InChI Key InChIKey=DJWGTNCIAUYYCQ-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50426797   

LigandPNGBDBM50426797(CHEMBL2322764)
Affinity DataIC50:  29nMAssay Description:Inhibition of GST-fused human recombinant PI3Kbeta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50426797(CHEMBL2322764)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-fused human recombinant PI3Kalpha expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50426797(CHEMBL2322764)
Affinity DataIC50:  155nMAssay Description:Inhibition of PI3Kalpha in human PC3 cells assessed as inhibition of AKT phosphorylation at Ser473 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50426797(CHEMBL2322764)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin)-mediated 3,4,5-inositoltriphosphate formation after 30 mins by TAMRA-PIP3-based competitive fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50426797(CHEMBL2322764)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of GST-fused human recombinant PI3Kdelta expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50426797(CHEMBL2322764)
Affinity DataIC50:  155nMAssay Description:Inhibition of PI3Kalpha-mediated AKT Ser 473 phosphorylation in human PC3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50426797(CHEMBL2322764)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of GST-fused human recombinant PI3Kgamma expressed in baculovirus infected SF9 cells after 1 hr by scintillation proximity assay in presen...More data for this Ligand-Target Pair