BDBM50427353 CHEMBL2325736::US10654855, Example 69::US11236095, Example 69::US9492453, 69

SMILES CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(CC1)c1ncnc2[nH]ccc12)c1ccc(Cl)cc1

InChI Key InChIKey=GHETXRUUPUTFCN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50427353   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  6.90nMpH: 7.5 T: 2°CAssay Description:This assay detects inhibitors of AKT1 (PKBα) kinase activity using Caliper LabChip LC3000. The Caliper off-chip incubation mobility shift assay...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  7nMAssay Description:Inhibition of recombinant Akt1 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  153nMAssay Description:Inhibition of recombinant ROCK2 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  6.90nMAssay Description:Following addition of compound or control to the assay plate, 6p1 peptide mix containing 3 μM substrate (5-FAM-GRPRTSSFAEG-CONH2; CRB) and 40 &#...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant Akt2 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  8.01E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by ionworks assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  6.90nMAssay Description:For Echo dosing the solvent was 100% DMSO. A master plate was prepared with 40 ul of 10 mM stock from our Primary Liquid Store in quadrant 1 of a Lab...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50427353(CHEMBL2325736 | US10654855, Example 69 | US1123609...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant Akt3 (unknown origin) using 5-FAM-labeled peptide as substrate after 1 hr by caliper off-chip incubation mobility shift ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed