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BDBM50427605 CHEMBL2322932

SMILES: C[C@H](C[C@@H](O)C(F)(F)C(=O)c1ccc2OCOc2c1)O[Si](C(C)C)(C(C)C)C(C)C

InChI Key: InChIKey=SRDKTVQFVYGSMJ-HUUFDIDONA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50427605   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA-B receptor 1/2


(Homo sapiens (Human))
BDBM50427605
PNG
(CHEMBL2322932)
Show SMILES C[C@H](C[C@@H](O)C(F)(F)C(=O)c1ccc2OCOc2c1)O[Si](C(C)C)(C(C)C)C(C)C
Show InChI InChI=1/C22H34F2O5Si/c1-13(2)30(14(3)4,15(5)6)29-16(7)10-20(25)22(23,24)21(26)17-8-9-18-19(11-17)28-12-27-18/h8-9,11,13-16,20,25H,10,12H2,1-7H3/t16-,20-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



Purdue University

Curated by ChEMBL


Assay Description
Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hr...


J Med Chem 56: 2456-65 (2013)


Article DOI: 10.1021/jm301805e
BindingDB Entry DOI: 10.7270/Q25T3MTS
More data for this
Ligand-Target Pair