BDBM50428028 CHEMBL1257064

SMILES Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1

InChI Key InChIKey=WRKPZSMRWPJJDH-UHFFFAOYSA-N

Data  5 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50428028   

TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
The University Of Texas Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50428028(CHEMBL1257064)
Affinity DataEC50:  30nMAssay Description:Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428028(CHEMBL1257064)
Affinity DataIC50:  930nMAssay Description:Inhibition of full-length rat GST-tagged CK1delta using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting ...More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428028(CHEMBL1257064)
Affinity DataIC50:  157nMAssay Description:Inhibition of porcupine in HEK293T cells transfected with Wnt3A-expressing vector assessed as suppression of Wnt/beta-catenin signaling after 22 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428028(CHEMBL1257064)
Affinity DataIC50:  320nMAssay Description:Inhibition of rat recombinant CK1delta kinase domain using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counti...More data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428028(CHEMBL1257064)
Affinity DataIC50:  4.03E+3nMAssay Description:Inhibition of human recombinant CK1epsilon using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov counting methodMore data for this Ligand-Target Pair
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Ulm University Hospital

Curated by ChEMBL
LigandPNGBDBM50428028(CHEMBL1257064)
Affinity DataIC50:  40nMAssay Description:Inhibition of rat GST-tagged CK1delta M82F mutant at 10 uM using alpha-casein as substrate after 30 mins in presence of [gamma-32P]-ATP by Cherenkov ...More data for this Ligand-Target Pair