BDBM50428113 CHEMBL2331663::US8791131, 172

SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CO)c3c2n1

InChI Key InChIKey=ARICVBDWIFNOOD-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50428113   

LigandPNGBDBM50428113(CHEMBL2331663 | US8791131, 172)
Affinity DataKi:  0.532nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428113(CHEMBL2331663 | US8791131, 172)
Affinity DataKi:  0.532nM ΔG°:  -12.6kcal/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50428113(CHEMBL2331663 | US8791131, 172)
Affinity DataKi:  0.842nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50428113(CHEMBL2331663 | US8791131, 172)
Affinity DataKi:  0.842nM ΔG°:  -12.4kcal/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent