BDBM50428339 CHEMBL2331714

SMILES NC1=NC2(CC2CCS1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F

InChI Key InChIKey=COCAUCFPFHUGAA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50428339   

TargetBeta-secretase 2(Rattus norvegicus)
Temple University

Curated by ChEMBL
LigandPNGBDBM50428339(CHEMBL2331714)
Affinity DataIC50:  11nMAssay Description:Inhibition of BACE2-mediated TMEM27 cleavage in rat INS-1E cells expressing doxycycline-dependent human full-length TMEM27 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Temple University

Curated by ChEMBL
LigandPNGBDBM50428339(CHEMBL2331714)
Affinity DataIC50:  12nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP695 assessed as decrease in amyloid beta 40 level after 18 to 20 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed