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BDBM50429303 CHEMBL2334150

SMILES: Cc1c(Cl)cccc1C(=O)N1CCC[C@@H](C1)c1nc(no1)-c1ccc(F)cc1

InChI Key: InChIKey=ZDIZJQHQFVQGCK-GGYSOQFKNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50429303   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM50429303
PNG
(CHEMBL2334150)
Show SMILES Cc1c(Cl)cccc1C(=O)N1CCC[C@@H](C1)c1nc(no1)-c1ccc(F)cc1
Show InChI InChI=1/C21H19ClFN3O2/c1-13-17(5-2-6-18(13)22)21(27)26-11-3-4-15(12-26)20-24-19(25-28-20)14-7-9-16(23)10-8-14/h2,5-10,15H,3-4,11-12H2,1H3/t15-/s2
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MMDB

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Similars

Article
PubMed
n/an/a 956n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human 11-beta HSD1 transfected in HEK293 cell microsomes assessed as decrease in [3H]cortisol generation using [3H]cortisone as substra...


Eur J Med Chem 62: 1-10 (2013)


Article DOI: 10.1016/j.ejmech.2012.12.059
BindingDB Entry DOI: 10.7270/Q2GH9K9M
More data for this
Ligand-Target Pair