BDBM50429757 CHEMBL1998736::N-(2-Fluorophenyl)Cinnamamide

SMILES Fc1ccccc1NC(=O)\C=C\c1ccccc1

InChI Key InChIKey=GFAVMCPSQILRPK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50429757   

Target72 kDa type IV collagenase(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429757(N-(2-Fluorophenyl)Cinnamamide | CHEMBL1998736)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human recombinant MMP2 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429757(N-(2-Fluorophenyl)Cinnamamide | CHEMBL1998736)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant MMP9 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50429757(N-(2-Fluorophenyl)Cinnamamide | CHEMBL1998736)
Affinity DataIC50: 4.17E+3nMAssay Description:Inhibition of human recombinant MMP1 using succinylated gelatin as substrate incubated for 30 mins prior to substrate addition measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50429757(N-(2-Fluorophenyl)Cinnamamide | CHEMBL1998736)
Affinity DataIC50: 7.37E+3nMAssay Description:Inhibition of recombinant His-tagged human EGFR (645 to 1186 residues) cytoplasmic domain expressed in baculovirus infected Sf9 cells incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50429757(N-(2-Fluorophenyl)Cinnamamide | CHEMBL1998736)
Affinity DataIC50: 7.37E+3nMAssay Description:Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article