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BDBM50429818 CHEMBL2337691

InChI string: InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)

SMILES: ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1

InChI Key: InChIKey=ZVJILQAAQQNBOP-UHFFFAOYSA-N

Data: 1 KI  8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50429818   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
PDB
MMDB

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2.10E+4n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ADAMTS5 using bovine nasal cartilage aggrecan as substrate assessed as inhibition of 1772-AGEG neopeptide formation i...


Eur J Med Chem 62: 379-94 (2013)

More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
PDB
MMDB

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n/an/a 19n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP13 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate additio...


Eur J Med Chem 62: 379-94 (2013)

More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 3.80n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP2 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...


Eur J Med Chem 62: 379-94 (2013)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 2.70E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP1 using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to substrate addition...


Eur J Med Chem 62: 379-94 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
PDB
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n/an/a 620n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ADAMTS5 expressed in HEK293 cells using Abz-TESEwSRGAIY-Dpa-KK as substrate measured for 2 hrs by fluorometric analys...


Eur J Med Chem 62: 379-94 (2013)

More data for this
Ligand-Target Pair
ADAM17


(Homo sapiens (Human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
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n/an/a 590n/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Inhibition of recombinant human ADAM-17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 30 mins measured every 15 secs ...


J Med Chem 56: 8089-103 (2013)

More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4)


(Homo sapiens (Human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
PDB
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PubMed
n/an/a 3.50E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant ADAMTS4 expressed in HEk293 cells using FAM-AEwLQGRPISIAK-TAMRA as substrate measured for 15 mins by fluorometric ana...


Eur J Med Chem 62: 379-94 (2013)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 310n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro- Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 2 hrs prior to ...


Eur J Med Chem 62: 379-94 (2013)

More data for this
Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14)


(Homo sapiens (Human))
BDBM50429818
PNG
(CHEMBL2337691)
Show SMILES ONC(=O)CNS(=O)(=O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O5S/c18-15(17-19)10-16-23(20,21)14-8-6-13(7-9-14)22-11-12-4-2-1-3-5-12/h1-9,16,19H,10-11H2,(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 310n/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
Inhibition of recombinant human MMP-14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate incubated for 4 hrs measured ...


J Med Chem 56: 8089-103 (2013)

More data for this
Ligand-Target Pair