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BDBM50431724 CHEMBL2346719

SMILES: Cc1c(nn(C)c1-c1ccc(F)cc1)C(=O)Nc1ccnc(Cl)c1

InChI Key: InChIKey=HHQNDKZHVIQITA-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50431724   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50431724
PNG
(CHEMBL2346719)
Show SMILES Cc1c(nn(C)c1-c1ccc(F)cc1)C(=O)Nc1ccnc(Cl)c1
Show InChI InChI=1S/C17H14ClFN4O/c1-10-15(17(24)21-13-7-8-20-14(18)9-13)22-23(2)16(10)11-3-5-12(19)6-4-11/h3-9H,1-2H3,(H,20,21,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 56n/an/an/an/an/an/a



SK Biopharmaceuticals

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as calcium mobilization by FLIPR assay


Bioorg Med Chem Lett 23: 2134-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.116
BindingDB Entry DOI: 10.7270/Q20R9QR5
More data for this
Ligand-Target Pair