BDBM50433038 CHEMBL2375957::US8633204, 299

SMILES COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCC(N)=O)CC3)c2=O)cc1F

InChI Key InChIKey=OKZQPXUPXMKTBL-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50433038   

LigandChemical structure of BindingDB Monomer ID 50433038BDBM50433038(CHEMBL2375957 | US8633204, 299)
Affinity DataKi:  0.312nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50433038BDBM50433038(CHEMBL2375957 | US8633204, 299)
Affinity DataIC50: 0.686nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50433038BDBM50433038(CHEMBL2375957 | US8633204, 299)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of AKT phosphorylation at Ser 473 in human BT20 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50433038BDBM50433038(CHEMBL2375957 | US8633204, 299)
Affinity DataKi:  11nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed