BDBM50433041 CHEMBL2375960::US8633204, 306

SMILES Cc1nc(N)nc2n([C@@H]3CC[C@@H](CC3)OCC(N)=O)c(=O)c(cc12)-c1cnn(C)c1

InChI Key InChIKey=LOYNAYXFINASCA-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50433041   

LigandPNGBDBM50433041(CHEMBL2375960 | US8633204, 306)
Affinity DataKi:  25nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandPNGBDBM50433041(CHEMBL2375960 | US8633204, 306)
Affinity DataIC50: 58.1nMpH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kα using an in vitro kinase assay. PI3-Kα activity is measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50433041(CHEMBL2375960 | US8633204, 306)
Affinity DataKi:  93nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
LigandPNGBDBM50433041(CHEMBL2375960 | US8633204, 306)
Affinity DataIC50: 988nMAssay Description:Inhibition of AKT phosphorylation at Ser 473 in human BT20 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed