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BDBM50433395 CHEMBL2375624

SMILES: COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1

InChI Key: InChIKey=JSKOBBAIXHUWTC-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50433395   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433395
PNG
(CHEMBL2375624)
Show SMILES COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C25H24N4O/c1-30-20-11-9-19(10-12-20)28-14-16-29(17-15-28)25-18-24(23-8-4-5-13-26-23)27-22-7-3-2-6-21(22)25/h2-13,18H,14-17H2,1H3
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PubMed
n/an/an/an/a 100n/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1 in presence of Co2+


J Med Chem 56: 3996-4016 (2013)

More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50433395
PNG
(CHEMBL2375624)
Show SMILES COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C25H24N4O/c1-30-20-11-9-19(10-12-20)28-14-16-29(17-15-28)25-18-24(23-8-4-5-13-26-23)27-22-7-3-2-6-21(22)25/h2-13,18H,14-17H2,1H3
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n/an/an/an/a>1.00E+5n/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 2 in presence of Mn2+


J Med Chem 56: 3996-4016 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433395
PNG
(CHEMBL2375624)
Show SMILES COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C25H24N4O/c1-30-20-11-9-19(10-12-20)28-14-16-29(17-15-28)25-18-24(23-8-4-5-13-26-23)27-22-7-3-2-6-21(22)25/h2-13,18H,14-17H2,1H3
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PubMed
n/an/an/an/a 5.10E+3n/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1 in presence of Mn2+


J Med Chem 56: 3996-4016 (2013)

More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM50433395
PNG
(CHEMBL2375624)
Show SMILES COc1ccc(cc1)N1CCN(CC1)c1cc(nc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C25H24N4O/c1-30-20-11-9-19(10-12-20)28-14-16-29(17-15-28)25-18-24(23-8-4-5-13-26-23)27-22-7-3-2-6-21(22)25/h2-13,18H,14-17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.10E+3n/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human methionine aminopeptidase 1 in presence of Zn2+


J Med Chem 56: 3996-4016 (2013)

More data for this
Ligand-Target Pair