BDBM50433842 CHEMBL2382402

SMILES CC(Sc1nc(-c2ccc(Cl)c(Cl)c2)c(C#N)c(=O)[nH]1)C(=O)Nc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=YDJOCTZRWDYNJT-UHFFFAOYSA-N

Data  4 KI  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50433842   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50433842(CHEMBL2382402)
Affinity DataKi:  5.10nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50433842(CHEMBL2382402)
Affinity DataKi:  7.80nMAssay Description:Inhibition of human carbonic anhydrase 12 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50433842(CHEMBL2382402)
Affinity DataKi:  19nMAssay Description:Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50433842(CHEMBL2382402)
Affinity DataKi:  48nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs at 4 degC measured for 10 to 100 secs by stopped-flow carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50433842(CHEMBL2382402)
Affinity DataKd:  5.10E+3nMAssay Description:Binding affinity to human recombinant carboxy-terminal avi-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50433842(CHEMBL2382402)
Affinity DataIC50:  750nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins b...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50433842(CHEMBL2382402)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed