BDBM50434069 CHEMBL2381339::US9676792, Compound 24

SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)c3cccc4CCN(c34)c2n1)C(=O)N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=UWHQAHZPBAISBU-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50434069   

TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434069(CHEMBL2381339 | US9676792, Compound 24)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of GST-tagged full length human ERK5 transfected in HEK293 cells assessed as inhibition of AP1 transcriptional activity after 24 hrs by du...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434069(CHEMBL2381339 | US9676792, Compound 24)
Affinity DataIC50:  199nM EC50:  260nMpH: 7.5Assay Description:Kinase activity was determined in an assay volume of 40 μl in kinase buffer (50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 1 mM 2-mercaptoethanol) contai...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50434069(CHEMBL2381339 | US9676792, Compound 24)
Affinity DataIC50:  5nMAssay Description:In vitro kinase assays were conducted at Invitrogen (Madison, Wis.) using the SelectScreen Kinase Profiling Service.More data for this Ligand-Target Pair
In DepthDetails US Patent