BDBM50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound)

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1

InChI Key: InChIKey=CVWXJKQAOSCOAB-UHFFFAOYSA-N

Data: 91 IC50  857 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 960 hits for monomerid = 50300690   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.623	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.236	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.00200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.93	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.06	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	57.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835V] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 [D835V] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 [F691L] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [R834Q] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [564-710,762-958] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Blk (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	20.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.623	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.236	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.00200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.623	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 1 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.06	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	57.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	37.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dimer of Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50300690 (CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair