BDBM50434806 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide::CHEMBL2387080::GDC 0032::GDC-0032::Roche RG7604::Taselisib::US10851091, Compound taselisib::US8242104, Compound 196

SMILES: CC(C)n1nc(C)nc1-c1cn2CCOc3cc(ccc3-c2n1)-c1cnn(c1)C(C)(C)C(N)=O

InChI Key: InChIKey=BEUQXVWXFDOSAQ-UHFFFAOYSA-N

Data: 19 KI  8 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50434806   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	374	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	292	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		0.970	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		9.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		23.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		23.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Human)	BDBM50434806 (CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...) Show SMILES Show InChI	GoogleScholar	UniChem		1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair