BDBM50434978 CHEMBL2385899

SMILES OC(=O)Cn1c2CCN(Cc2c2cc(ccc12)C(F)(F)F)C(=O)c1cccc2ccccc12

InChI Key InChIKey=DFVBLFJUHBOAGA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50434978   

TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50434978(CHEMBL2385899)
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50434978(CHEMBL2385899)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human CRTH2 receptor expressed in HEK293 cells assessed as inhibition of PGD2-induced calcium flux after 5 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50434978(CHEMBL2385899)
Affinity DataIC50: 70nMAssay Description:Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting analysis in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50434978(CHEMBL2385899)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at CRTH2 receptor in human eosinophils assessed as inhibition of PGD2-induced cell shape change incubated for 1 hr prior to PGD2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50434978(CHEMBL2385899)
Affinity DataIC50: 380nMAssay Description:Antagonist activity at human CRTH2 receptor expressed in HEK293 cells assessed as inhibition of PGD2/forskolin-induced intracellular cAMP production ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50434978(CHEMBL2385899)
Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of [3H]PGD2 from recombinant human prostanoid DP1 receptor expressed in CHO cells after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50434978(CHEMBL2385899)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human prostanoid TP2 receptor expressed in HEK293 cells assessed as inhibition of calcium flux after 30 to 40 mins by FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed