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BDBM50435665 CHEMBL2391602

SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1cccc(Oc2nc(C)cc(C)c2C#N)c1

InChI Key: InChIKey=YMBFHHCJVITIQM-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50435665   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50435665
PNG
(CHEMBL2391602)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cccc(Oc2nc(C)cc(C)c2C#N)c1
Show InChI InChI=1S/C21H19N3O3S/c1-14-7-9-19(10-8-14)28(25,26)24-17-5-4-6-18(12-17)27-21-20(13-22)15(2)11-16(3)23-21/h4-12,24H,1-3H3
UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 310n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins


Bioorg Med Chem Lett 23: 3609-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.04.014
BindingDB Entry DOI: 10.7270/Q2K938XJ
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50435665
PNG
(CHEMBL2391602)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cccc(Oc2nc(C)cc(C)c2C#N)c1
Show InChI InChI=1S/C21H19N3O3S/c1-14-7-9-19(10-8-14)28(25,26)24-17-5-4-6-18(12-17)27-21-20(13-22)15(2)11-16(3)23-21/h4-12,24H,1-3H3
UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 310n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 mins


Bioorg Med Chem Lett 24: 1133-7 (2014)


Article DOI: 10.1016/j.bmcl.2013.12.127
BindingDB Entry DOI: 10.7270/Q2445NZJ
More data for this
Ligand-Target Pair