BindingDB BDBM50436850 CERITINIB::CHEMBL2403108::LDK378::US10053458, Comparative Example 2::US10618884, Example 16::US9809572, Example 16

BDBM50436850 CERITINIB::CHEMBL2403108::LDK378::US10053458, Comparative Example 2::US10618884, Example 16::US9809572, Example 16

SMILES Cc1cc(c(cc1C2CCNCC2)OC(C)C)Nc3ncc(c(n3)Nc4ccccc4S(=O)(=O)C(C)C)Cl

InChI Key InChIKey=VERWOWGGCGHDQE-UHFFFAOYSA-N

Data 4 KI 174 IC50 1 Kd 11 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 216 hits for monomerid = 50436850

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 0.200nMAssay Description:Inhibition of ALK (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
4/13/2014
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 0.200nMAssay Description:Inhibition of ALK (unknown origin) after 60 minsMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
4/13/2014
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 0.25nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/23/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

Ki: 0.400nMAssay Description:Inhibition of ROS1 L2026M mutant (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/18/2020
Entry Details Article
PubMed

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

Ki: 0.400nMAssay Description:Binding affinity to recombinant human ROS1 L2026M mutant assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
10/13/2025
Entry Details
PubMed

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 0.610nMAssay Description:Inhibition of N-terminal GST tagged wild-type human ALK cytoplasmic domain (1058-1620 amino acids) expressed Sf9 cells pre-incubated for 30 mins befo...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/25/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

Ki: 0.700nMAssay Description:Inhibition of wild type ROS1 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/18/2020
Entry Details Article
PubMed

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

Ki: 0.700nMAssay Description:Binding affinity to recombinant human ROS1 assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
10/13/2025
Entry Details
PubMed

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 0.830nMAssay Description:Inhibition of wild type N-terminal GST tagged ALK L1196M mutant cytoplasmic domain (1058 to 1620 end residues) (unknown origin) expressed in Sf21 cel...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/23/2023
Entry Details
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 1nMT: 2°CAssay Description:A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
10/18/2018
Entry Details
US Patent
PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 1nMAssay Description:Inhibition of ALK (unknown origin) preincubated for 10 mins followed by addition of substrate and ATP for 25 mins by caliper EZ reader methodMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/23/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 1.10nMAssay Description:Inhibition of human ALK L1196M mutant expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured a...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/25/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 1.20nMAssay Description:Inhibition of wild type N-terminal GST tagged ALK cytoplasmic domain (1058 to 1620 end residues) (unknown origin) expressed in Sf21 cells incubated f...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/23/2023
Entry Details
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

Kd: 1.30nMAssay Description:Binding affinity to wild-type human partial length ALK (I1088 to E1409 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/15/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 1.60nMAssay Description:Inhibition of human ALK S1206Y mutant expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured a...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/25/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 1.90nMAssay Description:Inhibition of human ALK G1269A mutant expressed Sf9 cells pre-incubated for 30 mins before addition of Ulight-CKKSRGDYMTMQIG substrate and measured a...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/25/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2nMAssay Description:Inhibition of ROS1 (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/16/2018
Entry Details Article
PubMed

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2nMAssay Description:Inhibition of N-terminal GST-tagged human ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
2/20/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2nMAssay Description:Inhibition of ROS1 (unknown origin) using peptide substrate incubated for 60 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/22/2022
Entry Details Article
PubMed

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in baculovirus expression system usin...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/20/2020
Entry Details Article
PubMed

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.10nMAssay Description:Inhibition of crizotinib-resistant ALK G1269A mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/27/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS1 (1883 to 2347 residues) expressed in baculovirus expression system using IRS1 as substrate...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/29/2022
Entry Details Article
PubMed

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.20nMAssay Description:Inhibition of EML4-fused ALK (unknown origin) by cell-based assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
4/13/2014
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.30nMAssay Description:Inhibition of ALK (unknown origin) using peptide as substrate after 60 mins by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/16/2018
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.30nMAssay Description:Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in Baculovirus expression system using srctide as ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
2/20/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.40nMAssay Description:Inhibition of wild-type ALK (unknown origin) incubated for 1 hrMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/22/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.40nMAssay Description:Inhibition of crizotinib-resistant ALK F1174L mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/27/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) T1151 insertion mutant expressed in baculovirus ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/20/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.60nMAssay Description:Inhibition of ALK (unknown origin) incubated for 1 hr and measured by mobility shift assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/19/2023
Entry Details
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) cytoplasmic domain expressed in baculovirus expression system using...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.90nMAssay Description:Inhibition of ALK (unknown origin) using peptide substrate incubated for 60 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/22/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.90nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
10/12/2025
Entry Details
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/20/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 2.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) C1156Y mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/20/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.10nMAssay Description:Inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as su...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
2/20/2021
Entry Details Article
PubMed

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) cytoplasmic domain L1196M mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.10nMAssay Description:Inhibition of human ALK assessed as decreased enzymatic reactions measured after 1 hr by mobility shift assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/19/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.20nMAssay Description:Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus infected Sf21 insect cells using Src...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/26/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.20nMAssay Description:Inhibition of N-terminal GST-tagged human wild type ALK (1058 to 1620 residues) cytoplasmic domain expressed in baculovirus infected Sf21 cells incub...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/21/2023
Entry Details
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.30nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
8/23/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.40nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) G1269A mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/20/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.40nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
7/29/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.40nMAssay Description:Inhibition of purified ALK (unknown origin) after 60 mins by ELISA kinase assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/7/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK (1058 to 1620 residues) expressed in baculovirus expression system using Srctide as substra...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/29/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.5nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
4/18/2024
Entry Details
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 3.90nMAssay Description:Inhibition of ALK (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
2/23/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 4.20nMAssay Description:Inhibition of crizotinib-resistant ALK C1156Y mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
3/27/2022
Entry Details Article
PubMed PDB

3D Structure (crystal)

Proto-oncogene tyrosine-protein kinase ROS(Human)
Taibah University

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 4.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ROS (1883 to 2347 residues) cytoplasmic domain expressed in baculovirus expression system using...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
2/25/2021
Entry Details Article
PubMed

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 4.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK cytoplasmic domain (1058 to 1620 residues) S1206Y mutant expressed in baculovirus expressio...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/20/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

ALK tyrosine kinase receptor(Human)
University of Michigan Comprehensive Cancer Center

Curated by ChEMBL

BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)

IC50: 5nMAssay Description:The determination of IC50 of the inhibiting effect to kinase ALK 96-well plates was coated under 37° C. with coating buffer (125 ul/well) overnig...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
10/7/2019
Entry Details
US Patent
PDB

3D Structure (crystal)

Displayed 1 to 50 (of 216 total ) | Next | Last >>

Filter my 216 hits

Targets 32▿
- ALK tyrosine kinase receptor 116
- Platelet-derived growth factor receptor alpha/beta 19
- Epidermal growth factor receptor 18
- Proto-oncogene tyrosine-protein kinase ROS 15
- Hepatocyte growth factor receptor 7
- Insulin receptor 5
- ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4 4
- Receptor-type tyrosine-protein kinase FLT3 3
- Tyrosine-protein kinase JAK2 2
- Proto-oncogene tyrosine-protein kinase receptor Ret 2
- Insulin-like growth factor 1 receptor 2
- High affinity nerve growth factor receptor 2
- H-2 class II histocompatibility antigen gamma chain 2
- Transcription factor ETV6 1
- Tyrosine-protein kinase BTK 1
- Tyrosine-protein kinase ABL1 1
- Replicase polyprotein 1ab 1
- ALK tyrosine kinase receptor/Nucleophosmin 1
- Tyrosine-protein kinase JAK1 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- Platelet-derived growth factor receptor alpha 1
- ALK tyrosine kinase receptor [L1196M] 1
- Serine/threonine-protein kinase PAK 2 1
- ATP-dependent translocase ABCB1 1
- Tyrosine-protein kinase SYK 1
- Testis-specific serine/threonine-protein kinase 1 1
- Tyrosine-protein kinase JAK3 1
- Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977] 1
- Activated CDC42 kinase 1 1
- Rho-associated protein kinase 2 1
- Tyrosine-protein kinase ZAP-70 1
- BDNF/NT-3 growth factors receptor 1
- ...
Publications 47▿
- J Med Chem 56: 5675-90 (2014) 31
- Clin Cancer Res 22: 5527-5538 18
- US Patent US10618884 (2020) 16
- US Patent US9809572 (2017) 16
- Eur J Med Chem 136: 497-510 (2017) 14
- Eur J Med Chem 143: 123-136 (2018) 10
- Bioorg Med Chem 27: (2019) 6
- Proc Natl Acad Sci U S A 112: 3493-8 6
- Bioorg Med Chem 24: 207-19 (2016) 6
- Bioorg Med Chem Lett 29: 1514-1517 (2019) 6
- Bioorg Med Chem 28: (2020) 5
- Bioorg Med Chem 37: (2021) 5
- Eur J Med Chem 171: 297-309 (2019) 5
- Eur J Med Chem 158: 322-333 (2018) 5
- Eur J Med Chem 214: (2021) 5
- J Med Chem 63: 13994-14016 (2020) 4
- Eur J Med Chem 238: (2022) 4
- Eur J Med Chem 123: 80-89 (2016) 4
- Eur J Med Chem 241: (2022) 4
- Bioorg Med Chem Lett 75: (2022) 4
- Bioorg Med Chem 66: (2022) 3
- Eur J Med Chem 134: 348-356 (2017) 3
- Bioorg Med Chem Lett 25: 3992-8 (2015) 3
- Eur J Med Chem 224: (2021) 3
- Bioorg Med Chem Lett 26: 1090-1096 (2016) 2
- US Patent US10053458 (2018) 2
- Bioorg Med Chem 47: (2021) 2
- Bioorg Med Chem Lett 27: 2185-2191 (2017) 2
- Bioorg Med Chem Lett 26: 1720-5 (2016) 2
- Bioorg Med Chem 28: (2020) 2
- J Med Chem 56: 5673-4 (2014) 2
- J Med Chem 62: 10927-10954 (2019) 1
- ACS Chem Biol 11: 2195-205 (2016) 1
- J Med Chem 62: 2618-2637 (2019) 1
- Eur J Med Chem 212: (2021) 1
- J Med Chem 62: 10005-10025 (2019) 1
- Eur J Med Chem 151: 304-314 (2018) 1
- Eur J Med Chem 126: 536-549 (2017) 1
- Eur J Med Chem 144: 386-397 (2018) 1
- Eur J Med Chem 164: 193-213 (2019) 1
- J Med Chem 64: 16328-16348 (2021) 1
- J Med Chem 58: 9296-9308 (2015) 1
- Eur J Med Chem 257: 1
- Antimicrob Agents Chemother 64: (2020) 1
- Eur J Med Chem 86: 438-48 (2014) 1
- J Med Chem 67: 14702-14722 1
- US Patent US12129258 (2024) 1
Institutions 29▿
- Shenyang Pharmaceutical University 59
- Genomics Institute of The Novartis Research Foundation 33
- Suzhou Zelgen Biopharmaceuticals 32
- ARIAD Pharmaceuticals, Inc. 18
- Harvard Medical School 14
- Korea Research Institute of Chemical Technology 12
- Arromax Pharmatech 6
- Pfizer 6
- Cancer Hospital of China Medical University 5
- University of Michigan 4
- Chongqing Medical University 3
- Taibah University 3
- University of Michigan Comprehensive Cancer Center 2
- Shanghai Institute of Materia Medica (Simm) 2
- Chungbuk National University 2
- University of Science & Technology 2
- Icahn School of Medicine At Mount Sinai 1
- West China Hospital of Sichuan University 1
- Weifang Medical University 1
- Primegene (Beijing) 1
- National Clinical Research Center For Geriatrics 1
- Institut Pasteur Korea 1
- Dana-Farber Cancer Institute 1
- Boston University 1
- Jinan University 1
- University of Washington 1
- The Institute of Cancer Research 1
- Rheinische Friedrich-Wilhelms-University of Bonn 1
- Zhejiang University 1
Affinity: 0.20 to 1.0E+6 nM▿
- Ki 7
- IC50 197
- Kd 1
- EC50 11
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1