BDBM50436850 CERITINIB::CHEMBL2403108::LDK378::US10053458, Comparative Example 2::US10618884, Example 16::US9809572, Example 16

SMILES: Cc1cc(c(cc1C2CCNCC2)OC(C)C)Nc3ncc(c(n3)Nc4ccccc4S(=O)(=O)C(C)C)Cl

InChI Key: InChIKey=VERWOWGGCGHDQE-UHFFFAOYSA-N

Data: 4 KI  174 IC50  1 Kd  11 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 216 hits for monomerid = 50436850   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase/endoribonuclease IRE1 [547-977] (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	182	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Insulin receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Human)	BDBM50436850 (CHEMBL2403108 | CERITINIB | US10053458, Comparativ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair