BDBM50438735 CHEMBL2414670

SMILES Cc1noc(C[C@H]2CC[C@@H](CC2)c2ccc(cc2)N2CCOc3ncnc(N)c3C2=O)n1

InChI Key InChIKey=YHEFHAAZUQQTLM-WKILWMFISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50438735   

TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50438735(CHEMBL2414670)
Affinity DataIC50:  60nMAssay Description:Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50438735(CHEMBL2414670)
Affinity DataIC50:  23nMAssay Description:Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50438735(CHEMBL2414670)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human DGAT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50438735(CHEMBL2414670)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ACAT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed