BDBM50438870 8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinoline-2,4-dione (4)::CHEMBL2420501

SMILES Oc1ccc(cc1)-n1c2cc(Cl)ccc2cc2c1nc(=O)[nH]c2=O

InChI Key InChIKey=GCWHBACBRZCRNJ-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50438870   

TargetDNA-(apurinic or apyrimidinic site) endonuclease(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of APE-1 (unknown origin) using double-stranded AP-site containing DNA as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50:  7.04E+3nMAssay Description:Inhibition of TDP2 (unknown origin) using 5'-Y-TCCGTTGAAGCCTGCTTT-3' as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataEC50:  1.66E+3nMAssay Description:Inhibition of TDP2 (unknown origin) using 4-nitrophenyl phenylphosphonate as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50:  4.00E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50:  2.30E+3nMpH: 7.5Assay Description:Ten-million cells (1 x 107), either human, chicken DT40 wild type, or knockout for TDP2 and complemented with human TDP2, were collected, washed, and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50: >1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C](Mus musculus (Mouse))
National Institutes Of Health

LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50:  3.50E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 2(Homo sapiens (Human))
University Of Manchester

Curated by ChEMBL
LigandPNGBDBM50438870(8-Chloro-10-(4-hydroxyphenyl)pyrimido[4,5-b]quinol...)
Affinity DataIC50:  3.90E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed