BDBM50438936 CHEMBL2420629::GNE-617

SMILES: c1cc(ccc1CNC(=O)c2ccc3nccn3c2)S(=O)(=O)c4cc(cc(c4)F)F

InChI Key: InChIKey=XRDVXQQZLHVEQZ-UHFFFAOYSA-N

Data: 15 IC50  2 EC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50438936   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 1A2 (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Nicotinamide phosphoribosyltransferase (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Nicotinamide phosphoribosyltransferase (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C19 (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	25
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Nicotinamide phosphoribosyltransferase (Mouse)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
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Nicotinamide phosphoribosyltransferase (Mouse)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
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Nicotinamide phosphoribosyltransferase (Rat)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Human)	BDBM50438936 (CHEMBL2420629 | GNE-617) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair