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BDBM50438959 CHEMBL2420640

SMILES: O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1ccc2nncn2c1

InChI Key: InChIKey=PAQFKPYHUCJENG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50438959   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50438959
PNG
(CHEMBL2420640)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1ccc2nncn2c1
Show InChI InChI=1S/C20H16N4O3S/c25-20(16-8-11-19-23-22-14-24(19)13-16)21-12-15-6-9-18(10-7-15)28(26,27)17-4-2-1-3-5-17/h1-11,13-14H,12H2,(H,21,25)
PDB
MMDB

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PC cid
PC sid
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Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Forma Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged NAMPT (unknown origin) expressed in Escherichia coli BL21 using nicotinamide as substrate preincubated for 15 min...


J Med Chem 56: 6413-33 (2013)


Article DOI: 10.1021/jm4008664
BindingDB Entry DOI: 10.7270/Q2H996MB
More data for this
Ligand-Target Pair