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BDBM50438970 CHEMBL2420663

SMILES: O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1nc2ccncc2s1

InChI Key: InChIKey=WCFDLJZPPCGVGR-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50438970   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50438970
PNG
(CHEMBL2420663)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1nc2ccncc2s1
Show InChI InChI=1S/C20H15N3O3S2/c24-19(20-23-17-10-11-21-13-18(17)27-20)22-12-14-6-8-16(9-7-14)28(25,26)15-4-2-1-3-5-15/h1-11,13H,12H2,(H,22,24)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Forma Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged NAMPT (unknown origin) expressed in Escherichia coli BL21 using nicotinamide as substrate preincubated for 15 min...


J Med Chem 56: 6413-33 (2013)


Article DOI: 10.1021/jm4008664
BindingDB Entry DOI: 10.7270/Q2H996MB
More data for this
Ligand-Target Pair