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BDBM50439018 CHEMBL2420831

SMILES: Clc1cccc(Cl)c1C(=O)Nc1cc[nH]c(=O)c1

InChI Key: InChIKey=JVXCQSWKORAHLL-UHFFFAOYSA-N

Data: 2 KI

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50439018   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50439018
PNG
(CHEMBL2420831)
Show SMILES Clc1cccc(Cl)c1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C12H8Cl2N2O2/c13-8-2-1-3-9(14)11(8)12(18)16-7-4-5-15-10(17)6-7/h1-6H,(H2,15,16,17,18)
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PC cid
PC sid
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Similars

Article
PubMed
60n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin)


Eur J Med Chem 67: 175-87 (2013)


Article DOI: 10.1016/j.ejmech.2013.03.070
BindingDB Entry DOI: 10.7270/Q2416ZGB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50439018
PNG
(CHEMBL2420831)
Show SMILES Clc1cccc(Cl)c1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C12H8Cl2N2O2/c13-8-2-1-3-9(14)11(8)12(18)16-7-4-5-15-10(17)6-7/h1-6H,(H2,15,16,17,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
MMDB
PC cid
PC sid
UniChem

Similars

Article
PubMed
100n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of JAK1 (unknown origin)


Eur J Med Chem 67: 175-87 (2013)


Article DOI: 10.1016/j.ejmech.2013.03.070
BindingDB Entry DOI: 10.7270/Q2416ZGB
More data for this
Ligand-Target Pair