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BDBM50439038 CHEMBL2420850

SMILES: COc1cccc(C(=O)Nc2ccncc2)c1Cl

InChI Key: InChIKey=APPLHBUWQDBEOB-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50439038   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM50439038
PNG
(CHEMBL2420850)
Show SMILES COc1cccc(C(=O)Nc2ccncc2)c1Cl
Show InChI InChI=1S/C13H11ClN2O2/c1-18-11-4-2-3-10(12(11)14)13(17)16-9-5-7-15-8-6-9/h2-8H,1H3,(H,15,16,17)
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PC cid
PC sid
UniChem

Similars

Article
PubMed
3.20E+3n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of JAK2 (unknown origin)


Eur J Med Chem 67: 175-87 (2013)


Article DOI: 10.1016/j.ejmech.2013.03.070
BindingDB Entry DOI: 10.7270/Q2416ZGB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM50439038
PNG
(CHEMBL2420850)
Show SMILES COc1cccc(C(=O)Nc2ccncc2)c1Cl
Show InChI InChI=1S/C13H11ClN2O2/c1-18-11-4-2-3-10(12(11)14)13(17)16-9-5-7-15-8-6-9/h2-8H,1H3,(H,15,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>3.50E+3n/an/an/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of JAK1 (unknown origin)


Eur J Med Chem 67: 175-87 (2013)


Article DOI: 10.1016/j.ejmech.2013.03.070
BindingDB Entry DOI: 10.7270/Q2416ZGB
More data for this
Ligand-Target Pair