BDBM50440614 CHEMBL2426364

SMILES O=C(N1CCC(CC1)N1CCCC1)c1ccc(C(=O)N2CCC(CC2)N2CCCC2)c(Nc2ccccc2)c1

InChI Key InChIKey=PQOOIERVZAXHBP-UHFFFAOYSA-N

Data  19 IC50  3 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50440614   

TargetScm-like with four MBT domains protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SFMBT1 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  120nMAssay Description:Inhibition of L3MBTL3 (unknown origin) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetPHD finger protein 23(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PHF23 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  64nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 4(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of L3MBTL4 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  9.40E+3nMAssay Description:Binding affinity to L3MBTL1 (unknown origin) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  120nMAssay Description:Binding affinity to L3MBTL3 (unknown origin) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JARID1A (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsoform 4 of Lethal(3)malignant brain tumor-like protein 1 (4)(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase UHRF1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of UHRF1 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTP53-binding protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CBX7 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMBT domain-containing protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 1(Homo sapiens)
University Of North Carolina

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of His-tagged L3MBTL1 (unknown origin) using H4K20Me1 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetLethal(3)malignant brain tumor-like protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  24nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase UHRF1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of UHRF1 tandem tudor domain (121 to 286) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H3K9Me3 as substrate incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CBX7 (8 to 62) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H3K9Me3 as substrate incubated for 30 mins at room...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTP53-binding protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  1.37E+4nMAssay Description:Inhibition of 53BP1 (1485 to 1611) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H4K20Me2 as substrate incubated for 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMBT domain-containing protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  7.80E+4nMAssay Description:Inhibition of MBTD1 (130 to 566) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H4K20Me1 as substrate incubated for 30 mins at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPHD finger protein 23(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of GST-tagged PHF23 (unknown origin) using H3K4Me3 as substrate incubated for 30 mins at room temperature followed by incubation under dar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of GST-tagged Jarid1A (unknown origin) using H3K4Me3 as substrate incubated for 30 mins at room temperature followed by incubation under d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 3(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50:  49nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair