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BDBM50441383 CHEMBL2435406

SMILES: O=C1N(Cc2c[nH]c3ccccc23)CCCC11CCN(CC1)c1cnccn1

InChI Key: InChIKey=CCGWDYLPWSYNLM-UHFFFAOYSA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50441383   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Orexin receptor type 2


(Homo sapiens (Human))
BDBM50441383
PNG
(CHEMBL2435406)
Show SMILES O=C1N(Cc2c[nH]c3ccccc23)CCCC11CCN(CC1)c1cnccn1
Show InChI InChI=1S/C22H25N5O/c28-21-22(7-12-26(13-8-22)20-15-23-9-10-24-20)6-3-11-27(21)16-17-14-25-19-5-2-1-4-18(17)19/h1-2,4-5,9-10,14-15,25H,3,6-8,11-13,16H2
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Similars

Article
PubMed
309n/an/an/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Antagonist activity at human OX2 receptor expressed in HEK cells assessed as inhibition of orexin A-induced Ca2+ accumulation after 1 hr by Fluo-4-AM...


J Med Chem 56: 7590-607 (2013)


Article DOI: 10.1021/jm4007627
BindingDB Entry DOI: 10.7270/Q2M90B3S
More data for this
Ligand-Target Pair