BDBM50443625 CHEMBL3092448::US9216998, 25

SMILES FC(F)(F)c1c(CCc2ccccc2)n2CCOc3cccc1c23

InChI Key InChIKey=FZBIFJDVJQDOQI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50443625   

TargetEndothelial lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50:  39nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50:  31nMpH: 7.2Assay Description:To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50:  39nMAssay Description:Inhibition of endothelial lipase in human cells after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50:  39nMAssay Description:Inhibition of human endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50:  31nMAssay Description:Inhibition of endothelial lipase in mouse cells after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Mus musculus (Mouse))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50443625(CHEMBL3092448 | US9216998, 25)
Affinity DataIC50:  31nMAssay Description:Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed