BindingDB PrimarySearch

BDBM50443628 CHEMBL3092468::US9174993, 35::US9221828, 35

SMILES: Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1

InChI Key: InChIKey=DDKHTWASHUKHLD-UHFFFAOYSA-N

Data: 11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50443628
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9174993 (2015) BindingDB Entry DOI: 10.7270/Q2MK6BPF
Sanofi US Patent					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	24
Sanofi US Patent					Assay Description The enzyme reaction was carried out in a buffer containing 25 mM Tris-HCl (pH 7.4), 5 mM MgCl2, 2 mM MnCl2, 2 mM DTT, and 0.03% bovine serum albumi...				US Patent US9221828 (2015) BindingDB Entry DOI: 10.7270/Q2GX49DW
Sanofi US Patent					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R & D Curated by ChEMBL					Assay Description Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
Sanofi R & D Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk2 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R & D Curated by ChEMBL					Assay Description Inhibition of human SGK2 in presence of 500 uM ATP				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
Sanofi R & D Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk3 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R & D Curated by ChEMBL					Assay Description Inhibition of human SGK3 in presence of 500 uM ATP				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
Sanofi R & D Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Inhibition of recombinant human SGK-1 expressed in baculovirus expression system using (5(6)-carboxyfluorescein)-RPRAATF-NH2 as substrate preincubate...				ACS Med Chem Lett 4: 1022-4 (2013) Article DOI: 10.1021/ml400389a BindingDB Entry DOI: 10.7270/Q2XS5WVS
Temple University School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R & D Curated by ChEMBL					Assay Description Inhibition of human CYP3A4 midazolam site in human liver microsomes using midazolam as substrate by LC-MS/MS analysis				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
Sanofi R & D Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R & D Curated by ChEMBL					Assay Description Inhibition of human CYP3A4 testosterone site in human liver microsomes using midazolam as substrate by LC-MS/MS analysis				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
Sanofi R & D Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R & D Curated by ChEMBL					Assay Description Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
Sanofi R & D Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Temple University School of Pharmacy Curated by ChEMBL					Assay Description Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hr...				ACS Med Chem Lett 4: 1022-4 (2013) Article DOI: 10.1021/ml400389a BindingDB Entry DOI: 10.7270/Q2XS5WVS
Temple University School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50443628 (CHEMBL3092468 \| US9174993, 35 \| US9221828, 35) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R & D Curated by ChEMBL					Assay Description Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
Sanofi R & D Curated by ChEMBL					More data for this Ligand-Target Pair