BDBM50446130 AG-014699::AG-14447::RUCAPARIB CAMSYLATE::Rucaparib

SMILES: CNCc1ccc(cc1)c2c3c4c(cc(cc4[nH]2)F)C(=O)NCC3

InChI Key: InChIKey=HMABYWSNWIZPAG-UHFFFAOYSA-N

Data: 9 KI  70 IC50  12 Kd  2 EC50

PDB links: 5 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 103 hits for monomerid = 50446130   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
GDH/6PGL endoplasmic bifunctional protein (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	172	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP3 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	267	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP4 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	503	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP8 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP9 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP10 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP11 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP12 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP14 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP16 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Protein mono-ADP-ribosyltransferase PARP3 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform epsilon (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK3 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK4 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.36E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 4 (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Glycogen synthase kinase-3 beta (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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DNA polymerase alpha catalytic subunit (Human)	BDBM50446130 (AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair