BDBM50446303 CHEMBL3109338
SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CCNC[C@@H]3F)c2n1
InChI Key InChIKey=PPPOUAQYRUUFNJ-RXVVDRJESA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50446303
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
Array Biopharma
Curated by ChEMBL
Array Biopharma
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Mus musculus (mouse))
Array Biopharma
Curated by ChEMBL
Array Biopharma
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Array Biopharma
Curated by ChEMBL
Array Biopharma
Curated by ChEMBL
Affinity DataIC50: 499nMAssay Description:Inhibition of cFMS (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Array Biopharma
Curated by ChEMBL
Array Biopharma
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair