BDBM50447182 CHEMBL3113192::US10752581, Compound 62

SMILES COc1ccc2nc(NS(=O)(=O)c3ccc(NCc4cccc(OC)c4O)cc3)sc2c1

InChI Key InChIKey=OFKPCFOWCAYUCL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447182   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50447182(CHEMBL3113192 | US10752581, Compound 62)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of N-terminal His6-tagged human reticulocyte 15-LOX1 using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50447182(CHEMBL3113192 | US10752581, Compound 62)
Affinity DataIC50:  5.10E+3nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Eastern Virginia Medical School

US Patent
LigandPNGBDBM50447182(CHEMBL3113192 | US10752581, Compound 62)
Affinity DataIC50:  260nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Eastern Virginia Medical School

US Patent
LigandPNGBDBM50447182(CHEMBL3113192 | US10752581, Compound 62)
Affinity DataIC50:  260nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed