BDBM50448118 CHEMBL3122113::US10590114, No. 80::US11111235, No. 80::US11591316, Compound 80::US9932325, Example 80

SMILES: Cc1c(cn(n1)C(C)(C)C#N)Nc2ncc(c(n2)NC)C(F)(F)F

InChI Key: InChIKey=ZPPUMAMZIMPJGP-UHFFFAOYSA-N

Data: 3 KI  26 IC50

PDB links: 2 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50448118   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Human)	BDBM50448118 (CHEMBL3122113 | US9932325, Example 80 | US10590114...) Show SMILES Show InChI	GoogleScholar	UniChem		150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair