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BDBM50448631 CHEMBL3127498

SMILES: Clc1ccc(OCCCCCCNC(=O)[C@@H]2C[C@H]2c2cccnc2)cc1

InChI Key: InChIKey=CAIUCFWHCBXQLC-MYKRFBFLNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50448631   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50448631
PNG
(CHEMBL3127498)
Show SMILES Clc1ccc(OCCCCCCNC(=O)[C@@H]2C[C@H]2c2cccnc2)cc1
Show InChI InChI=1/C21H25ClN2O2/c22-17-7-9-18(10-8-17)26-13-4-2-1-3-12-24-21(25)20-14-19(20)16-6-5-11-23-15-16/h5-11,15,19-20H,1-4,12-14H2,(H,24,25)/t19-,20+/s2
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.60n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human full-length NAMPT expressed in Escherichia coli Rosetta DE3 using nicotinamide as substrate preincubated fo...


J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair