BDBM448932 5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine::BDBM50455056::US10696678, Example 27

SMILES CC1(C)CCc2nc3c(F)cc(cc3n12)-c1nc(Nc2ccc(CN3CCNCC3)cn2)ncc1F

InChI Key InChIKey=DHPLYCJQWJHXFH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 448932   

TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM448932(5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK4 (unknown origin) after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM448932(5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of recombinant human full length CDK1/Cyclin D3 expressed in baculovirus infected Sf9 insect cells using histone H1 substrate after 90 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448932(5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  1.37E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448932(5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM448932(5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  3.70E+3nMAssay Description:In vitro inhibition of CDK (CDK1, CDK4, CDK6) activity by compounds of the present invention was tested by the following method.1. Preparation of kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Beijing University Of Technology

Curated by ChEMBL
LigandPNGBDBM448932(5-Fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-b...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of recombinant human full length CDK6 expressed in baculovirus infected Sf9 insect cells using histone H1 substrate after 90 mins by ADP-G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed