BDBM50458159 Nirogacestat::PF 03084014::PF 3084014::PF-03084014::PF-3084014
SMILES CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(cn1)C(C)(C)CNCC(C)(C)C
InChI Key InChIKey=VFCRKLWBYMDAED-REWPJTCUSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50458159
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human gamma-secretase by cell based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in notch signaling by fetal thymus organ culture assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of gamma secretase isolated from human HeLa cell derived P2 membrane assessed as reduction in amyloid beta (1 to 40 residues) using recomb...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human gamma-secretaseMore data for this Ligand-Target Pair