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BDBM50459705 CHEMBL4218467

SMILES: COc1c(ccc2OC(C)(C)C=Cc12)C(=O)Cc1ccccc1

InChI Key: InChIKey=JQWXIWSOTKQBJX-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50459705   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor 1-alpha


(Homo sapiens (Human))
BDBM50459705
PNG
(CHEMBL4218467)
Show SMILES COc1c(ccc2OC(C)(C)C=Cc12)C(=O)Cc1ccccc1
Show InChI InChI=1S/C20H20O3/c1-20(2)12-11-16-18(23-20)10-9-15(19(16)22-3)17(21)13-14-7-5-4-6-8-14/h4-12H,13H2,1-3H3
PDB

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antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 880n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of HIF-1alpha in human HRE-A549 cells pre-incubated for 1 hr before exposure to hypoxia for 24 hrs by HRE-luciferase reporter gene assay


J Med Chem 61: 9266-9286 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00971
BindingDB Entry DOI: 10.7270/Q269766D
More data for this
Ligand-Target Pair